we are

Cosmoceutical Research Center

RESEARCH, MANUFACTURING, AND PRODUCT SAFETY

we are

pioneers in cosmetics industry

As a Research Center, CRC’s expertise has been in continuous demand. CRC has been a pioneer in the cosmetic industry by developing new cosmeceutical products with techniques like transdermal penetration.

we are

in business since 1995

The CRC has been manufacturing beauty products for more than 23 years.

about us

Who we are

Vartan Libaridian R.Ph, PH.D.

Co-founder and President

Dr. Vartan brings over 30 years of experience as a pharmacist and R&D in both pharmacy and cosmetic chemistry. He enjoys creating orchid variants, classical music, and collecting old model cars and airplanes.


Michelle Volynsky, Ph.D.

Co-founder and Vice-President

Dr. Michelle has over 25 years of experience doing R&D in organic chemistry and has focused on cosmetic chemistry for over 20 years. She enjoys yoga, studying Reiki, reading, classical music, being in nature, and most of all, her four grandkids.

All at a glance

CRC is equipped with sophisticated laboratory mixing and physicochemical evaluation equipment for advanced formulation techniques. As a Manufacturing Center, CRC has the latest advanced manufacturing technology and equipment, helping to compound and produce consistently high quality products.

  • Although CRC has its own in-house product Evaluation Center, with state-of-the-art skin evaluation equipment which tests for product safety, it also has a worldwide network of International Skin Research Centers for regional studies.

  • CRC is registered with the Food and Drug Administration (FDA) for Cosmetics and Drug licensing and is validated for Organic Products Manufacturing by Oregon Tilth.

activity

What we do

CRC concentrates on developing its own line of quality cosmeceutical skin treatment products

Cosmoceutical Research Center distributes its products to Italy, Philippines, China, Taiwan, Iran, Mexico, Middle East, South America, Russia and the USA. The Middle East branch of the company covers the entire Middle East

about product

Our features

  1. CRC Product Line

    This product line encompasses a full skin treatment regimen

  2. Solutions

    It addresses various skin conditions including acne, hyperpigmentation, melasma, rosecea, and unbalanced, aging skin

  3. Care

    Incorporation of transdermal penetrating bases and breakthrough actives makes CRC products highly potent yet safe

storefront

Our products

CRC PRODUCT LINE

  • All
  • Cream
  • Other
products

Description

Acne cream

A combination of natural antimicrobial agents with reduced amounts of Benzoyl Peroxide, both in a penetrating base, provides a potent effect with a reduced inflammation of the skin. Benzoyl Peroxide is one of the most potent topical agents presently available to treat acne. However, it also has side effects such as irritation, and sensitization. The cream also contains encapsulated Tea Tree Oil, a natural antimicrobial agent, that suppresses the P.acnes population and manages inflammatory response caused by free fatty acids.

MASK CLEANSER

This product is a convenient combination of two entities: Mask and Cleanser. The mask is based on mud from the Dead Sea, which is rich in minerals. The cleanser is based on micro emulsion technology that makes it mild enough for all skin types. This combination provides deep but gentle cleansing of the skin due to emulsifying and ion exchange properties. Cations that are elctro statistically held at the skin surface are exchanged with the mud s loosely held cations. Thus, the Dead Sea mud will exchange inorganic mineral nutrients, such as calcium and phosphorus, for inorganic and organic undesirable components, such as dead cells, sweat, skin oil, dust, deodorants, and toxic elements covering the skin. The additional amount of cleanser, which is a micro emulsion of mild surfactant and oil, gently cleanses the skin without additional inflammation and keeps the lipid barrier intact. Also, Dead Sea mud provides the skin with smoothing and calming effects and decreases pore sizes.

s-ence

A rich day and night cream, S-ence delivers a fresh glowing appearance for dull, dry, aging skin. Microcollagen is re-enforced by Green Algae extract and a peptide. These active ingredients, in a highly penetrating base, stimulate synthesis of collagen and gulcosaminogycans, diminishing wrinkles and replenishing the skin. This cream contains phospholipids, the key ingredient in maintaining hydration levels of the skin.

Le-serum

Immediate superficial wrinkle reduction by moisture retention and relaxing muscle expression. It has both long and short-term benefits. In the short-term, the high concentration and molecular weight of Hyaluronic acid visibly improve skin’s texture and forms a smooth canvas on the skin. For the long-term, the presence of a specific neuropeptide (acetyl hexapeptide-8), in a highly penetrating base, relaxes muscle expression, targeting deeper wrinkles, helping to support younger looking skin.

Acetyl hexapeptide 8, which is also known as Argireline, is a peptide compound to reduce the appearance of wrinkles brought on by repeated facial expressions. When it comes to fine lines and wrinkles on the face, especially around the eyes and mouth; they usually form because of repeated facial emotions, such as smiling, frowning, or furrowing the brow in deep concentration or frustration. Acetyl hexapeptide 8 can temporarily get rid of wrinkles by intercepting messages from the brain, thereby preventing muscle contractions. The most obvious benefit is that its method of delivery is much less invasive than that of Botox or collagen injections, which can be extremely painful. Layer this serum under your nightly moisturiser, and you’ll spur your skin into regeneration while you sleep.

For all skin types.

Odorless, clear gel. Lightweight texture, fresh, invigorating scent. Since serum tends to be thinner than hydrating creams, it's able to penetrate more deeply into the skin, delivering active ingredients along the way. Apply once or twice a day in a circular motion onto the face. Allow a couple of minutes to dry before applying other product.

Hand, Foot & Elbow Cream

Hand, Foot & Elbow Cream when extra nourishment is essential for cracked, itchy and rough skin. Our thick and creamy blend is full of healing ingredients to relieve dry and itchy patches, sooth deep cracks and soften cuticles, saturates your skin with the hydration it needs to invert dryness and flaking, offers immediate relief and comfort, leaving your skin feeling super soft and nourished. Hand, Foot & Elbow Cream forms a thin protective layer on the skin, improving its healing effect. Due to unique technology of the formulation and vitamins A, E and Aloe Vera, providing extended moisturization penetrating deep into the dry skin layers, causes skin cells deep below the surface to better absorb and hold moisture. The cream is quickly absorbed, making your skin softer, smoother and restoring its elasticity. Reduces the appearance of hyperkeratosis, stimulates blood flow, increasing the capillary strength. It is a homogeneous white, odorless cream. Non-Greasy Apply to clean hands, feet, and elbows 1-2 times a day or as needed.

Firming Body Gel

This incredible body gel creates firmer skin, provides tautness and enhances your skin with hydration. Skin is toned, subtle and soft to the touch. It strengthens the composition of your skin while delivering a sculpted, pure skin texture. It targets the appearance of cellulite and improves skin condition, visibly firming, and smoothing hips and thighs for a more sleek shape. This refreshing cream-gel instantly absorbs to comfort and smooth your skin's surface. Highly penetrating activity of our gel, firms the skin, reducing water content and fat cells in body tissues. It speeds up the skin healing process. The gel forms an invisible film on the surface of your skin, significantly improving its moisturization, elasticity and making it look fresh for a prolonged period. It can be used to restore the skin firmness and elasticity after pregnancy or weight fluctuation. It is a homogeneous gel of greenish color with a slight pleasant aroma. Apply to cleaned body skin while massaging. Use daily.

Biochemical CRC Tattoo Remover System I + II

Provides a gradual destruction of the skin layers to remove color pigment.

Tattoo Remover I has a low pH and contains natural ingredients such as phytic acid and Emblica .

Tattoo Remover II is removing fragments of the pigments and initiate tissue repair,reducing scarring to a minimum.

However, the success of the procedure will also depends on Master's skills, equipment and the skin .

Training for the application and usage of the products is required.

PHYTIC TREATMENT CONCENTRATE

The Phytic Treatment Concentrate is based on phytic acid, an organic substance produced from brown rice. This concentrate is clinically proven to be comparable to a 50% glycolic acid solution without irritation or sensational effects. This unique treatment complex provides a variety of benefits such as lightening activity, reduction of acneic lesions, substantial reduction of pore size, regulation of sebum secretion, mild to moderate exfoliation, and smoothing effects. This treatment is customized for every patient and can only be performed by a doctor or esthetician. An application of the Phytic Treatment Concentrate dramatically enhances the results of many CRC products. It is also used in conjunction with laser, microdermabrasion, and other procedures.

Laminaria Cooling Mask

This Cooling Mask is a unique relaxing product providing a cooling effect for a prolonged period, very comforting, immediately cools skin on contact, with a significant increase during the first 20 minutes of application. There are times when skin begs for a fresh hit of soothing comfort - overexposer to the sun, post facial treatment, or when skin is irritated, is the ideal time to indulge yourself with high quality. Seaweed tones the skin, moisturizing and rejuvenating it. It is rich in vitamins A1, B1, B2, B6, C, E, K, and also, is a source of over 12 minerals. It contains natural Peppermint oil, which provides a cooling effect and antiseptic properties improving the skin immune system, boosts the elimination of toxins and stimulates blood circulation while soothing the skin. Mask is a homogeneous greenish mixture with a pleasant fresh odor. Apply directly to clean wet face or body skin for up to 30 minutes and wash off. The mask has a comfortable setting time that allows smooth application even for the inexperienced esthetician.

Chocolate Heating Wrap

Chocolate Heating Wrap is an intensive treatment reduces the visible signs of aging, saturated with a Vitamin Enriched formula to enhance the tone and firmness of skin’s look, while minimizing the appearance of fine lines and wrinkles. Wrap's active ingredients are rich with antioxidants to help refine your skin’s appearance. This Bodywrap/mask is a unique relaxing product providing a cozy warming effect for an extended period, which you begin to feel within the first 5 minutes following the application. Due to the fatty acids in chocolate, this wrap gives an excellent moisturization, giving your skin an instant explosion of long-lasting, healthy hydration, leaving the skin softer and smoother than before. Its anti-oxidizing properties protect the skin from free radicals, small reactive oxygen molecules that can damage our skin. Its lipolytic effect on the adipose (fat) cell membranes receptors activates the process of fat burn that visibly diminishes dimples. Chocolate Heating Wrap - is a homogeneous mass of chocolate color, with a pleasant cocoa butter smell. Apply to clean wet skin for 20-40 min and wash off.

Chocolate Heating Wrap

Chocolate Heating Wrap is an intensive treatment reduces the visible signs of aging, saturated with a Vitamin Enriched formula to enhance the tone and firmness of skin’s look, while minimizing the appearance of fine lines and wrinkles. Wrap's active ingredients are rich with antioxidants to help refine your skin’s appearance. This Bodywrap/mask is a unique relaxing product providing a cozy warming effect for an extended period, which you begin to feel within the first 5 minutes following the application. Due to the fatty acids in chocolate, this wrap gives an excellent moisturization, giving your skin an instant explosion of long-lasting, healthy hydration, leaving the skin softer and smoother than before. Its anti-oxidizing properties protect the skin from free radicals, small reactive oxygen molecules that can damage our skin. Its lipolytic effect on the adipose (fat) cell membranes receptors activates the process of fat burn that visibly diminishes dimples. Chocolate Heating Wrap - is a homogeneous mass of chocolate color, with a pleasant cocoa butter smell. Apply to clean wet skin for 20-40 min and wash off.

science

clinical trials

Clinical trial on the efficacy of a new anti-acne regimen in the treatment of mild to moderate acne vulagaris. The Clinical Trial was conducted at the Philippine Dermatologist Research and Testing Foundation that conducts research on topical medicines.

Objectives:

  • A. To determine the efficacy of CRC anti-acne skin regimen to help dry and prevent eruption of new acne.
  • B. To monitor the development of signs and symptoms of adverse reactions of the regimen when applied daily over the duration of the study. (Tolerability)
  • Test Regimen: Mask Cleanser and Acne Cream (CRC)
  • Panelist: 30 panelist ages 16-35 with mild to moderate acne.

CONCLUSION

Acne regimen consisting of Mask Cleanser and Acne Cream (CRC) is effective in the treatment of mild to moderate acne, with significant improvement from week 1 to week 4. It is safe regimen and was well tolerated by the panelists suffering from mild to moderate acne.

For the reduction of acne comedones, there was a significant improvement after week 1 (40%) compared to the baseline data. After week 2 (58%) week 3 (68%) and week 4 (72 %). This improvement is very satisfactory, considering that comedone extraction was not done.

Among the 3 types of acne lesions, the pustular lesions responded best to the acne regimen. As early as Week 1 there was already 70% improvement and at Week 2 and 3, the improvement increased significantly to 94% and 92% with 95% improvement at the end of Week 4.

Nodulo-cystic acne eruptions improved significantly from week 1 to week 4, 45%, 87%, 84% and 87% respectively.

Pustular and nodulo-cystic lesions do not usually improve with topical treatment alone. In clinical practice, patients suffering from pustular and nodulo-cystic type of acne are also given oral antibiotics in addition.

There was a significant improvement in the reduction of acne lesions as a whole (44%) as early as week 1 compared to the baseline data. Week 2 (62 %), Week 3 (70%) and Week 4 (76%). Data analysis used was T-Test paired samples.

PICTURES OF SOME PATIENTS BEFORE AND AFTER CRC ACNE TREATMENT STUDY ON CRC PHYTIC TREATMENT CONCENTRATE* part 1

This study was conducted to determine if exposure to the Phytic Treatment Concentrate can increase cell proliferation in the Mat-Tek EpiDerm skin model and also assesses the any tissue damage and changes in tissue viability after exposure to the test materials using standard H&E stain techniques and the metabolic dye MTT. Test materials: 1.CRC Phytic Treatment Concentrate 2. Glycolic Acid 50 % Solution For each test material the percent viability value for each replicate was plotted on the y-axis versus the exposure time on the x-axis. Histology were done on tissues (H&E staining and Ki-67 staining) analysis. Results: The level of cytotoxicity was determined in tissues after15 and 30 minutes of exposure to CRC Phytic Treatment Concentrate and after 15 minutes to Glycolic Acid 50% solution. One H&E stain was prepared from one tissue in each set. One Ki-67 (Mib-1) immunostain was prepared from another tissue in each set including negative controls. Mitoses in H&E stained issues were counted at 40X magnification and expressed as number per high power field (HPF). The epidermal thickness was measured using a micrometer ocular at 40X magnification, measuring from the base of the basal layer (equivalent of the basement membrane) to the bottom of the stratum granulosum.

PICTURES OF SOME PATIENTS BEFORE AND AFTER CRC ACNE TREATMENT STUDY ON CRC PHYTIC TREATMENT CONCENTRATE* part 2

After exposing tissue to Phytic Treatment Concentrate for 15 minutes the tissue shows all layers of normal skin, including a basal layer, spinous layer, granular layer and cornified layer. No abnormal or pathological processes are identified. After exposure for 30 minutes using the same material the tissue apparently represents epidermis, but there is widespread accumulation of granular material in both the basal and granular layer. The material appears, at least in part, to be situated intracellularly. The cells of the granular layer are partially torn apart. The cornified layer shows some parakeratosis. After exposuing tissue to Glycolic Acid 50% solution for 30 minutes the same changes as described for 30 minutes of exposure to Phytic Treatment Concentrate are present. Based on the results of the MTT assay, Phytic Treatment Concentrate is non-cytotoxic after exposure for 15 minutes but is cytotoxic after exposure for 30 minutes. Glycolic Acid 50% solution is cytotoxic after exposure for 15 minutes. Based on the results of the histology the tissue exposed to Phytic Treatment Concentrate for 15 minutes appeared normal with no abnormal or pathological processes identified. Mib-1 (Ki-67) stain is positive for cell proliferation. The tissue exposed to Phytic Treatment Concentrate for 30 minutes and Glycolic Acid 50% for 15 minutes show widespread accumulation of granular material in both the basal and granular layer. The cells of the granular layer are partially torn apart and the cornified layer shows some parkeratosis. The Mib-1 stain is negative. This is evidence of tissue damage.

Study of Tyrosinase Inhibitory Activity for Phytic Treatment Concentrate* part 1

Concerning functional cosmetic, tyrosinase-inhibitory activity and superoxide scavenging activity have become very interesting research targets. Tyrosinase plays an important role in the formation of melanin, because it facilitates melanization by catalyzing reaction from tyrosine to dopa and from dopa to dopaquinone, and probably from dihydroxy indole to indole-5, 6-quinone. Superoxides have some relationship with skin inflammation, cancer and aging. Therefore, the development of superoxide scavengers and tyrosinase inhibitors will contribute to the prevention of skin pigmentation and aging, and to the maintenance of skin health. The inhibition ratio against tysosinase activity will be calculated by the measurement of optical density at 475nm with a routine method. The mixture containing different concentrations of Kojic acid or the single concentration of Phytic Treatment Concentrate were incubated with the reaction mixture at 37 Degrees C for 20 minutes and absorbance was recorded at 475 nm. The inhibitory effect of the sample on the tyrosinase activity is represented as inhibition % compared with control. The relative inhibitory activity of the product and the means of the results are displayed as % vehicle control (lacking an inhibitor) as a function of inhibitory concentration (100 % represents 0% inhibitor).

Study of Tyrosinase Inhibitory Activity for Phytic Treatment Concentrate* part 2

The process of melanin biosynthesis a determinant of skin color, and its disturbance plays an important role in local hyperpigmentation such as melasma, and lentigo. Therefore, tyrosinase is a useful target in the fields of hyperpigmentation and cosmetic materials. Phytic Treatment Concentrate exhibited significant inhibitory effects on mushroom tyrosinase at more than 150 ug/ml. The product exhibited an IC50 values of 207 ug/ml on tyrosinase. Therefore, Phytic Treatment Concentrate exhibited similar order of magnitude (Y x10 ug/ml) in the level of potency with Kojic acid used as a positive control. From the fact that the activity of Phytic Treatment Concentrate is comparative order of magnitude with that of Kojic acid, therefore, this compound may serve in functional skin care products for whitening and photoprotective functions.